Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
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2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

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6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

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5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
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8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... ............................................................

11:29 AM  
Blogger sportmuscle said...

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Musculação, treino, academia
Suplementos Fisiculturismo
Fitness, sarado

6:11 PM  

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heaven42: Adeno-associated viruses

Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
Blogger 麗君 said...

色情網自拍影片色情文章比基尼成人動畫色瞇瞇影片網小弟貼影片bt成人成人 影片日本成人網站日本成人網站破解日本成人網址日本成人線上免費日本成人免費影片日本成人動畫日本曾根日本有碼 dvd 專賣店日本有碼進口dvd專賣店日本東洋影片視訊 辣妹g8成人下載av短片-免費a片亞亞 dvd 光碟嘿咻kiss168cu成人bt情色 網4u成人0401影音視訊交友愛情館本土自拍xd成人圖區新人淚成人色網kkg亞洲免費影片av影片欣賞性行為補給站999成人性站最愛78論壇最色情的網站最色情的遊戲最多人聊天室最大a片網

2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

KK777一夜激情聊天live show成人自拍貼圖自慰少婦自拍裸體圖片台灣色情成人網站情人視訊網情色留言板視訊美女免費視訊聊天室限制級極度震撼情色論壇色情特區自拍裸女貼圖潮吹性影片觀賞小穴情色片a圖片sex story性愛影片美女做愛成人色情網站性愛圖片成人情色貼圖全裸寫真集圖片走光圖女生陰毛自慰影片色情av1007成人色情聊天室女生自慰裸體照成人影音聊天台灣色情網站色情片打手槍情色天堂成人視訊聊天免費情色網站av網超性感辣妹激突成人論壇情色視訊聊天鹹濕成人網站av成人論壇免費美女視訊

12:23 AM  
Blogger 冠伶 said...

裸體寫真全裸美女圖片色情訊息黃色圖片自拍裸體圖片sex裸露圖片18限85cc a片台灣色情網站免費色情圖一夜激情聊天情色聊天室限制級爆乳女優作愛巨乳學院性愛情慾陰脣一夜情下體網愛聊天鹹濕做愛自拍成人圖庫成人影城性關係視訊情人性影片觀賞裸照淫美成人論壇av寫真自拍裸女貼圖av圖情色性愛貼圖成人vcdsexy辣妹視訊聊天色情視訊淫婦台灣情色論壇丁字褲貼圖免費a片影片淫蕩女人live show男女做愛火辣妹妹激情網愛聊天美女裸照免費色情網站

4:40 PM  
Blogger 胤麗娟珠 said...

性感辣妹辣妹聊天情色文學情色遊戲情色自拍情色聊天情趣聊天室情趣自拍免費情趣影片素人自拍情趣短片性感辣妹性感美女美女性感遊戲性感遊戲裸體遊戲美女裸體女生裸體正妹裸體做愛偷拍偷拍自拍性愛偷拍偷拍視訊一夜情視訊一夜情聊天室一夜情交流網一夜情色網洪爺色情貼85cc影片5278影片網77p2p影片洪爺免費色情85cc觀看5278貼圖區77p2p觀看洪爺成年人網85cc成人片sogo成人77p2p成人片洪爺貼圖85cc影片區go2av影片77p2p影片區洪爺色論壇85cc免費影片區go2免費影片77p2p免費影片區洪爺影城85cc影城go2影片77p2p影城

6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

xh美色網 免費a片下載嘟嘟情人色網影片 av,sex520免費影片 完全免費視訊聊天 777美女dvd辣妹視訊 免費視訊celia aio交友視訊愛情館 西門慶成人論壇 台中酒店S援交 sex888影片分享區高中生援交 一葉情貼影片區 1314視訊 情人線上aa片試看嘟嘟 情人視訊網a 妹妹視訊 情色網成人電影 xxxholic次元魔女 成人文學小弟弟貼影片區 亞亞成人館 ut成人聊天室 微風成人 go2av免費看影片 104黑色會美眉自慰 日本同志色教館情色文學成人小說 34c視訊辣妹美女sex888免費電影 情色視訊論壇 0204貼圖區免費色情電影 成人貼圖站 交友ggo 免費影片下載a gogo2sex日本 拓網交友視訊美女 080情人網伊利論壇 一本道 a片 東京熱免費成人影片觀賞 交友ggoo 夜未眠影片中心 34c情人視訊網 一夜情性 情色視訊 美女 亞洲禁果名模影城 日本av論壇 台南視訊34c美女館 bt論壇交友網成人情色視訊妹 免費情人視訊 性愛電影85cc 聊天室交友whei 38girl視訊美女 aa免費影片 獨秀視訊聊天室 av730美眉共國 辣妹哈啦聊天室

5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
Blogger 幸家陳瑋齊 said...

真得很不錯的blog,加油哦............................................................

8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... ............................................................

11:29 AM  
Blogger sportmuscle said...

Ola,

Musculação, treino, academia
Suplementos Fisiculturismo
Fitness, sarado

6:11 PM  

Post a Comment

<< Home

heaven42: Adeno-associated viruses

Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
Blogger 麗君 said...

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2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

KK777一夜激情聊天live show成人自拍貼圖自慰少婦自拍裸體圖片台灣色情成人網站情人視訊網情色留言板視訊美女免費視訊聊天室限制級極度震撼情色論壇色情特區自拍裸女貼圖潮吹性影片觀賞小穴情色片a圖片sex story性愛影片美女做愛成人色情網站性愛圖片成人情色貼圖全裸寫真集圖片走光圖女生陰毛自慰影片色情av1007成人色情聊天室女生自慰裸體照成人影音聊天台灣色情網站色情片打手槍情色天堂成人視訊聊天免費情色網站av網超性感辣妹激突成人論壇情色視訊聊天鹹濕成人網站av成人論壇免費美女視訊

12:23 AM  
Blogger 冠伶 said...

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4:40 PM  
Blogger 胤麗娟珠 said...

性感辣妹辣妹聊天情色文學情色遊戲情色自拍情色聊天情趣聊天室情趣自拍免費情趣影片素人自拍情趣短片性感辣妹性感美女美女性感遊戲性感遊戲裸體遊戲美女裸體女生裸體正妹裸體做愛偷拍偷拍自拍性愛偷拍偷拍視訊一夜情視訊一夜情聊天室一夜情交流網一夜情色網洪爺色情貼85cc影片5278影片網77p2p影片洪爺免費色情85cc觀看5278貼圖區77p2p觀看洪爺成年人網85cc成人片sogo成人77p2p成人片洪爺貼圖85cc影片區go2av影片77p2p影片區洪爺色論壇85cc免費影片區go2免費影片77p2p免費影片區洪爺影城85cc影城go2影片77p2p影城

6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

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5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
Blogger 幸家陳瑋齊 said...

真得很不錯的blog,加油哦............................................................

8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... ............................................................

11:29 AM  
Blogger sportmuscle said...

Ola,

Musculação, treino, academia
Suplementos Fisiculturismo
Fitness, sarado

6:11 PM  

Post a Comment

<< Home

heaven42: Adeno-associated viruses

Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
Blogger 麗君 said...

色情網自拍影片色情文章比基尼成人動畫色瞇瞇影片網小弟貼影片bt成人成人 影片日本成人網站日本成人網站破解日本成人網址日本成人線上免費日本成人免費影片日本成人動畫日本曾根日本有碼 dvd 專賣店日本有碼進口dvd專賣店日本東洋影片視訊 辣妹g8成人下載av短片-免費a片亞亞 dvd 光碟嘿咻kiss168cu成人bt情色 網4u成人0401影音視訊交友愛情館本土自拍xd成人圖區新人淚成人色網kkg亞洲免費影片av影片欣賞性行為補給站999成人性站最愛78論壇最色情的網站最色情的遊戲最多人聊天室最大a片網

2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

KK777一夜激情聊天live show成人自拍貼圖自慰少婦自拍裸體圖片台灣色情成人網站情人視訊網情色留言板視訊美女免費視訊聊天室限制級極度震撼情色論壇色情特區自拍裸女貼圖潮吹性影片觀賞小穴情色片a圖片sex story性愛影片美女做愛成人色情網站性愛圖片成人情色貼圖全裸寫真集圖片走光圖女生陰毛自慰影片色情av1007成人色情聊天室女生自慰裸體照成人影音聊天台灣色情網站色情片打手槍情色天堂成人視訊聊天免費情色網站av網超性感辣妹激突成人論壇情色視訊聊天鹹濕成人網站av成人論壇免費美女視訊

12:23 AM  
Blogger 冠伶 said...

裸體寫真全裸美女圖片色情訊息黃色圖片自拍裸體圖片sex裸露圖片18限85cc a片台灣色情網站免費色情圖一夜激情聊天情色聊天室限制級爆乳女優作愛巨乳學院性愛情慾陰脣一夜情下體網愛聊天鹹濕做愛自拍成人圖庫成人影城性關係視訊情人性影片觀賞裸照淫美成人論壇av寫真自拍裸女貼圖av圖情色性愛貼圖成人vcdsexy辣妹視訊聊天色情視訊淫婦台灣情色論壇丁字褲貼圖免費a片影片淫蕩女人live show男女做愛火辣妹妹激情網愛聊天美女裸照免費色情網站

4:40 PM  
Blogger 胤麗娟珠 said...

性感辣妹辣妹聊天情色文學情色遊戲情色自拍情色聊天情趣聊天室情趣自拍免費情趣影片素人自拍情趣短片性感辣妹性感美女美女性感遊戲性感遊戲裸體遊戲美女裸體女生裸體正妹裸體做愛偷拍偷拍自拍性愛偷拍偷拍視訊一夜情視訊一夜情聊天室一夜情交流網一夜情色網洪爺色情貼85cc影片5278影片網77p2p影片洪爺免費色情85cc觀看5278貼圖區77p2p觀看洪爺成年人網85cc成人片sogo成人77p2p成人片洪爺貼圖85cc影片區go2av影片77p2p影片區洪爺色論壇85cc免費影片區go2免費影片77p2p免費影片區洪爺影城85cc影城go2影片77p2p影城

6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

xh美色網 免費a片下載嘟嘟情人色網影片 av,sex520免費影片 完全免費視訊聊天 777美女dvd辣妹視訊 免費視訊celia aio交友視訊愛情館 西門慶成人論壇 台中酒店S援交 sex888影片分享區高中生援交 一葉情貼影片區 1314視訊 情人線上aa片試看嘟嘟 情人視訊網a 妹妹視訊 情色網成人電影 xxxholic次元魔女 成人文學小弟弟貼影片區 亞亞成人館 ut成人聊天室 微風成人 go2av免費看影片 104黑色會美眉自慰 日本同志色教館情色文學成人小說 34c視訊辣妹美女sex888免費電影 情色視訊論壇 0204貼圖區免費色情電影 成人貼圖站 交友ggo 免費影片下載a gogo2sex日本 拓網交友視訊美女 080情人網伊利論壇 一本道 a片 東京熱免費成人影片觀賞 交友ggoo 夜未眠影片中心 34c情人視訊網 一夜情性 情色視訊 美女 亞洲禁果名模影城 日本av論壇 台南視訊34c美女館 bt論壇交友網成人情色視訊妹 免費情人視訊 性愛電影85cc 聊天室交友whei 38girl視訊美女 aa免費影片 獨秀視訊聊天室 av730美眉共國 辣妹哈啦聊天室

5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
Blogger 幸家陳瑋齊 said...

真得很不錯的blog,加油哦............................................................

8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... ............................................................

11:29 AM  
Blogger sportmuscle said...

Ola,

Musculação, treino, academia
Suplementos Fisiculturismo
Fitness, sarado

6:11 PM  

Post a Comment

<< Home

heaven42: Adeno-associated viruses

Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
Blogger 麗君 said...

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2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

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12:23 AM  
Blogger 冠伶 said...

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4:40 PM  
Blogger 胤麗娟珠 said...

性感辣妹辣妹聊天情色文學情色遊戲情色自拍情色聊天情趣聊天室情趣自拍免費情趣影片素人自拍情趣短片性感辣妹性感美女美女性感遊戲性感遊戲裸體遊戲美女裸體女生裸體正妹裸體做愛偷拍偷拍自拍性愛偷拍偷拍視訊一夜情視訊一夜情聊天室一夜情交流網一夜情色網洪爺色情貼85cc影片5278影片網77p2p影片洪爺免費色情85cc觀看5278貼圖區77p2p觀看洪爺成年人網85cc成人片sogo成人77p2p成人片洪爺貼圖85cc影片區go2av影片77p2p影片區洪爺色論壇85cc免費影片區go2免費影片77p2p免費影片區洪爺影城85cc影城go2影片77p2p影城

6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

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5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
Blogger 幸家陳瑋齊 said...

真得很不錯的blog,加油哦............................................................

8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... ............................................................

11:29 AM  
Blogger sportmuscle said...

Ola,

Musculação, treino, academia
Suplementos Fisiculturismo
Fitness, sarado

6:11 PM  

Post a Comment

<< Home

heaven42: Adeno-associated viruses

Wednesday, September 10, 2008

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

43 Comments:

Blogger Eric said...

Your blog is too outstanding and eye catching,
you should try blogerzoom for advertising
and marketing.

9:38 AM  
Blogger 明白 said...

快樂的微笑是保持生命康健的唯一藥石,它的價值千萬,卻不要花費一文錢 ..................................................

2:39 AM  
Blogger 元素 said...

pleasure to find such a good artical! please keep update!! ........................................

4:04 PM  
Blogger 光光 said...

想別人怎樣對你,你便怎樣對待別人。 ..................................................

5:25 AM  
Blogger 麗君 said...

色情網自拍影片色情文章比基尼成人動畫色瞇瞇影片網小弟貼影片bt成人成人 影片日本成人網站日本成人網站破解日本成人網址日本成人線上免費日本成人免費影片日本成人動畫日本曾根日本有碼 dvd 專賣店日本有碼進口dvd專賣店日本東洋影片視訊 辣妹g8成人下載av短片-免費a片亞亞 dvd 光碟嘿咻kiss168cu成人bt情色 網4u成人0401影音視訊交友愛情館本土自拍xd成人圖區新人淚成人色網kkg亞洲免費影片av影片欣賞性行為補給站999成人性站最愛78論壇最色情的網站最色情的遊戲最多人聊天室最大a片網

2:33 AM  
Blogger 葉雅慧 said...

Cheek brings success.........................................

4:25 AM  
Blogger 政倫政倫 said...

以簡單的行為愉悅他人的心靈,勝過千人低頭禱告。........................................

6:04 PM  
Blogger 逸凡逸凡 said...

KK777一夜激情聊天live show成人自拍貼圖自慰少婦自拍裸體圖片台灣色情成人網站情人視訊網情色留言板視訊美女免費視訊聊天室限制級極度震撼情色論壇色情特區自拍裸女貼圖潮吹性影片觀賞小穴情色片a圖片sex story性愛影片美女做愛成人色情網站性愛圖片成人情色貼圖全裸寫真集圖片走光圖女生陰毛自慰影片色情av1007成人色情聊天室女生自慰裸體照成人影音聊天台灣色情網站色情片打手槍情色天堂成人視訊聊天免費情色網站av網超性感辣妹激突成人論壇情色視訊聊天鹹濕成人網站av成人論壇免費美女視訊

12:23 AM  
Blogger 冠伶 said...

裸體寫真全裸美女圖片色情訊息黃色圖片自拍裸體圖片sex裸露圖片18限85cc a片台灣色情網站免費色情圖一夜激情聊天情色聊天室限制級爆乳女優作愛巨乳學院性愛情慾陰脣一夜情下體網愛聊天鹹濕做愛自拍成人圖庫成人影城性關係視訊情人性影片觀賞裸照淫美成人論壇av寫真自拍裸女貼圖av圖情色性愛貼圖成人vcdsexy辣妹視訊聊天色情視訊淫婦台灣情色論壇丁字褲貼圖免費a片影片淫蕩女人live show男女做愛火辣妹妹激情網愛聊天美女裸照免費色情網站

4:40 PM  
Blogger 胤麗娟珠 said...

性感辣妹辣妹聊天情色文學情色遊戲情色自拍情色聊天情趣聊天室情趣自拍免費情趣影片素人自拍情趣短片性感辣妹性感美女美女性感遊戲性感遊戲裸體遊戲美女裸體女生裸體正妹裸體做愛偷拍偷拍自拍性愛偷拍偷拍視訊一夜情視訊一夜情聊天室一夜情交流網一夜情色網洪爺色情貼85cc影片5278影片網77p2p影片洪爺免費色情85cc觀看5278貼圖區77p2p觀看洪爺成年人網85cc成人片sogo成人77p2p成人片洪爺貼圖85cc影片區go2av影片77p2p影片區洪爺色論壇85cc免費影片區go2免費影片77p2p免費影片區洪爺影城85cc影城go2影片77p2p影城

6:46 PM  
Blogger 品華yur1095is_newson1 said...

nice to know you ~........................................

11:08 AM  
Blogger 韋于倫成 said...

你的部落格感覺很棒,nice job!........................................

6:11 AM  
Blogger NealVa憲妤 said...

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5:58 PM  
Blogger ShilaL_Kappler said...

your english is incredible............................................................

7:37 PM  
Blogger HaroldM22 said...

Well done!............................................................

7:38 PM  
Blogger 彥安彥安 said...

幸福不是一切,人還有責任。..................................................

3:28 AM  
Blogger vickiekurt said...

不錯唷~我會常常來 >"<..................................................

1:46 AM  
Blogger 雲亨 said...

I guess I will need a lot..................................................

11:20 PM  
Blogger 穆靜如 said...

hello~來拜訪你囉~部落格很棒^^!......................................................................

1:26 AM  
Blogger 哲維維 said...

Pen and ink is wits plough. .................................................................                           

5:40 PM  
Blogger 誠侑誠侑 said...

Quality is better than quantity.................................................................

1:16 AM  
Blogger 啟均 said...

It takes all kinds to make a world.............................................................

6:40 PM  
Blogger 芸茂芸茂 said...

安安!剛開始玩這個,來這裡逛一下^^............................................................

7:38 AM  
Blogger 竹青 said...

這BLOG真是讓人意猶未盡!!..................................................................

5:14 PM  
Blogger JasonBirk佳琪 said...

人生的苦惱,不在擁有太少,而在奢望太多。..................................................

6:37 PM  
Blogger 偉倫s倪陳合恭陳陳sgdgd陳 said...

好的blog值得一推再推啦..................................................................

12:27 AM  
Blogger 李冠文 said...

有夢最美啦~~加油!元氣滿點!............................................................

12:28 AM  
Blogger 吳婷婷 said...

在你一無所有的時候 是誰在陪伴你 他便是你最重要的人............................................................

8:33 AM  
Blogger 淑凡 said...

天氣涼了~要注意身體喔@~@............................................................

11:30 PM  
Blogger 芳綠 said...

堅持是為著某種目的或目標,而持續不斷朝向既定方向努力的一種意念。..................................................

6:18 PM  
Blogger 俊宏淑松 said...

當最困難的時候,也就是離成功不遠的時候。..................................................

6:18 PM  
Blogger 王美妹 said...

世間唯一永恆的,就是改變..................................................

8:11 AM  
Blogger 徐俊賴靜雯賢 said...

Learn wisdom by the follies of others.............................................................

3:16 AM  
Blogger 許志蘇昶哲宏 said...

不會從失敗中找尋教訓的人,成功之路是遙遠的。.......................................................

7:21 AM  
Blogger 家唐銘 said...

After a storm comes a calm.............................................................

5:39 PM  
Blogger 燕明中延 said...

多謝大大的分享......good............................................................

3:30 AM  
Blogger 罗韬 said...

成熟,就是有能力適應生活中的模糊。............................................................

11:36 PM  
Blogger 皇紫勳紫勳豪 said...

這不過是滑一跤,並不是死掉而爬不起來了。..................................................

8:01 AM  
Blogger 幸家陳瑋齊 said...

真得很不錯的blog,加油哦............................................................

8:30 PM  
Blogger 翊翊翊翊張瑜翊翊翊 said...

人應該做自己認為對的事,而不是一味跟著群眾的建議走。..................................................

9:33 PM  
Blogger 筱趙趙婷趙趙趙 said...

缺少智慧,就是缺少一切..................................................

1:41 AM  
Blogger 彬彬哲宇 said...

找一個懂妳的人也期許自己做一個人懂別人的人.. ... .............................................