Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data

Adeno-associated viruses

Adeno-associated viruses, from the parvovirus family, are small viruses with a genome of single stranded DNA. The wild type AAV can insert genetic material at a specific site on chromosome 19 with near 100% certainty. But the recombinant AAV, which does not contain any viral genes and only the therapeutic gene, does not integrate into the genome. Instead the recombinant viral genome fuses at its ends via the ITR (inverted terminal repeats) recombination to form circular, episomal forms which are predicted to be the primary cause of the long term gene expression. There are a few disadvantages to using AAV, including the small amount of DNA it can carry (low capacity) and the difficulty in producing it. This type of virus is being used, however, because it is non-pathogenic (most people carry this harmless virus). In contrast to adenoviruses, most people treated with AAV will not build an immune response to remove the virus and the cells that have been successfully treated with it. Several trials with AAV are on-going or in preparation, mainly trying to treat muscle and eye diseases; the two tissues where the virus seems particularly useful. However, clinical trials have also been initiated where AAV vectors are used to deliver genes to the brain. This is possible because AAV viruses can infect non-dividing (quiescent) cells, such as neurons in which their genomes are expressed for a long time.

Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 25,000 genes of the human genome from both a physical and functional standpoint.

The project began in 1990 initially headed by James D. Watson at the U.S. National Institutes of Health. A working draft of the genome was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted by the private company Celera Genomics. Most of the sequencing was performed in universities and research centers from the United States, Canada and Britain. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project also has focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigational projects in modern science.

Planet (software)

In computing, Planet is a feed aggregator application designed to collect posts from the weblogs of members of an Internet community and display them on a single page. Planet runs on a web server. It creates pages with entries from the original feeds in chronological order, most recent entries first.

Planet is written in Python and maintained by Jeff Waugh and Scott James Remnant. Released under the Python License, Planet is free software.

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.

Aircraft

An aircraft is a vehicle which is able to fly through the Earth's atmosphere or through any other atmosphere. Most rocket vehicles are not aircraft because they are not supported by the surrounding air. All the human activity which surrounds aircraft is called aviation.

Manned aircraft are flown by a pilot. Until the 1960s, unmanned aircraft were called drones. During the 1960s, the U.S. military brought the term remotely piloted vehicle (RPV) into use. More recently the term unmanned aerial vehicle (UAV) has become common.

Custom software

Custom software (also known as Bespoke software) is a type of software that is developed either for a specific organization or function that differs from or is opposite of other already available software (also called off-the-shelf or COTSsoftware). It is generally not targeted to the mass market, but usually created for companies, business entities, and organizations. Custom software is also when companies or governments pay for customized software for budget or project managing.

Examples of bespoke software include ATMs and Supermarket checkout scanners. Other examples include many web sites and web-based applications.

However, according to the US government, million and multi-million dollar projects for custom software are available to bid on. (Refer to www.ccr.gov for more information.) Multiple companies with security clearances are able to bid for these massive projects. Other companies will successfully bid on these projects and then sell the project to another company for profit.

Data quality

1. Data Quality refers to the degree of excellence exhibited by the data in relation to the portrayal of the actual phenomena. GIS Glossary

2. The state of completeness, validity, consistency, timeliness and accuracy that makes data appropriate for a specific use. Government of British Columbia

3. The totality of features and characteristics of data that bears on their ability to satisfy a given purpose; the sum of the degrees of excellence for factors related to data